Effect of Eight Weeks Aerobic Exercise and Green Tea on Atherogenic Ratio and ABCG8 Gene Expression of PBMC Globules in Overweight Women

Objective: ABCG8 plays a crucial role in the reverse transfer of cholesterol from macrophages to the liver. The herbal compliments and regular physical improve the lipid profile and metabolic disorders. The aim of this study was to evaluate the effect of eight weeks aerobic exercise and green tea on the ABCG8 gene expression of peripheral blood mononuclear cell (PBMC) and the atherogenic ratio in overweight women. Materials and Methods: The studied population was the overweight women in Mashhad referring to athletic and aerobic gyms. Among the eligible population, 45 women were divided randomly into three groups of exercise, exercise with green tea supplement and control. Aerobic exercise sessions were held three times a week (8 week, per session 45 minutes), and the cases were provided with 500 milligrams of green tea supplement. After the separation of mononuclear blood globules, the changes in gene expression was performed via RT-PCR and the results were analyzed using SPSS version 16 software with the significance level of 0.05. Results: As a result of aerobic exercise, with or without the use of green tea supplement, ABCG8 gene expression has increased significantly in PBMC cells (P-value:0.001) and the atherogenic ratio has decreased significantly (P-value:0.001). Conclusion: Based on the findings of the present study, we may conclude that eight weeks of aerobic exercise along with usage of green tea supplement leads to an increase in ABCG8 gene expression and a decrease in the atherogenic ratio in overweight women compared to the aerobic exercise and placebo groups.